杀粉蝶霉素A Piericidin A

杀粉蝶霉素A  Piericidin A

NADH-ubiquinone oxidoreductase inhibitor

Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78， and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.

PRODUCT PROPERTIES

Alternative Name:

Piericidin A1， Shaoguanmycin B， Antibiotic MT 1882-I， Antibiotic SN 198E， Antibiotic IT 143D

RTECS:

YD4588000

Source/Host:

Isolated from Streptomyces sp. MST-AS5364.

Solubility:

Soluble in 100% ethanol， methanol， dimethyl formamide or DMSO.

Long Term Storage:

-20°C

Hazard:

VERY TOXIC.

MW:

415.6

CAS:

2738-64-9

Formula:

C₂₅H₃₇NO₄

Purity:

≥95% (HPLC)

Appearance:

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